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The region of the H-NMR spectrum related to the N-acetyl groups (2.151.90 ppm) was deconvoluted using three Lorentzian functions in order to calculate the specific concentrations of N-acetylglucosamine and N-acetyl galactosamine (GlycA) and N-acetylneuraminic acid (GlycB) [37]

Figure 6 Despite the large number of studies reporting positive biomedical effects, there are still safety and toxicity issues for the clinical use of selenium

The RNA was then reverse-transcribed into cDNA using the PrimeScript RT reagent kit (Takara, Dalian, China) ( -CT method

Targeting histone modifications Histone modification drugs are capable of rectifying dysregulated histone modification patterns within malignant cells to suppress the aberrant gene transcriptions associated with oncogenesis